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Search Results for " hgf receptor "

Targets Recommended: c-Met/HGFR

7

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T37596	Terevalefim	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Terevalefim 是干细胞生长因子的一种类似物，对c-Met 受体有选择性激活作用。
T76780	Onartuzumab RG-3638,PRO-14396,MetMAb	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Onartuzumab (MetMAb) 是一种人源化抗酪氨酸激酶 c-MET 单价单克隆抗体。Onartuzumab 具有抗肿瘤活性，对 HGF 结合、受体磷酸化和信号转导有抑制作用。
TP1990	Norleual
	Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
T76745	Ficlatuzumab
	Ficlatuzumab 是一种靶向人肝细胞生长因子 (HGF) 的单克隆抗体 (McAb)。Ficlatuzumab 能够阻断HGF/c-Met 信号通路的激活，抑制c-Met 受体介导的癌细胞增殖、迁移和侵袭。
T75940	Norleual TFA
	Norleual TFA 是一种血管紧张素 (Ang) IV 类似物，是一种肝细胞生长因子(HGF)/c-Met 抑制剂，IC50为 3 pM。Norleual TFA 还是一种AT4拮抗剂，具有强大的抗血管生成活性。
T71187	Foretinib phosphate
	Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
T28240	Ono 1301 Ono-1301,Ono1301
	Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only with induction of HGF but also by Ono

化合物

Cat.No: T37596

Target: c-Met/HGFR

Cat.No: T76780

Synonym: RG-3638,PRO-14396,MetMAb

Target: c-Met/HGFR

Cat.No: TP1990

Cat.No: T76745

Cat.No: T75940

Foretinib phosphate

Cat.No: T71187

Cat.No: T28240

Synonym: Ono-1301,Ono1301

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His) MET proto-oncogene, receptor tyrosine kinase,HG...	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.
TMPK-00499	HGFR/c-Met Protein, Cynomolgus, Recombinant (His) MET,oncogene MET,cMET,SF receptor,HGF/SF <...	Cynomolgus	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi) cMET,Met (c-Met),MET,HGF/SF receptor,SF	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPJ-00415	HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated SF receptor,HGF receptor,Scatter ...	Human	HEK293 Cells
	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domai...
TMPY-01895	HGFR/c-Met Protein, Mouse, Recombinant (hFc) c-Met,AI838057,MET proto-oncogene, receptor tyrosin...	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.
TMPJ-00375	HGF Protein, Human, Recombinant (His) Scatter factor,Hepatocyte growth factor,HGF,SF,Hepa...	Human	HEK293 Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelia...
TMPJ-00059	IL-7 Protein, Human, Recombinant (His) Interleukin-7,IL7,白细胞介素,IL-7,白介素	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe...
TMPH-03312	HGF Protein, Rat, Recombinant (GST)	Rat	E. coli
	Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. HGF Protein, Rat, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 55.0 kDa and the accession number is P17945.
TMPH-02922	SRPX2 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N...
TMPH-02923	SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli expression syste...
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....

重组蛋白

HGFR/c-Met Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01896

Species: Mouse

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00499

Species: Cynomolgus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00457

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated

Cat.No: TMPJ-00415

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01895

Species: Mouse

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant (His)

Cat.No: TMPJ-00375

Species: Human

Expression System: HEK293 Cells

IL-7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00059

Species: Human

Expression System: HEK293 Cells

HGF Protein, Rat, Recombinant (GST)

Cat.No: TMPH-03312

Species: Rat

Expression System: E. coli

SRPX2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02922

Species: Mouse

Expression System: Baculovirus Insect Cells

SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02923

Species: Mouse

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02237

Species: Human

Expression System: HEK293 Cells

TMPRSS2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02236

Species: Human

Expression System: E. coli

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